Hydrogen sulfide (H₂S), as a critical gasotransmitter, plays a dual role in regulating tumor growth depending on its concentration and tumor type. In nasopharyngeal carcinoma (NPC), systematic reviews have demonstrated the involvement of H₂S in multiple cellular processes, including cell proliferation, apoptosis, and metastasis. This study systematically explores the molecular mechanisms of H₂S in NPC, focusing on its role in modulating signaling pathways, for example, PI3K/AKT, Wnt/β-catenin, and ROS-mediated pathways. The findings indicate that H₂S exerts its effects by regulating the expression of oncogenes and tumor suppressor genes, altering the tumor microenvironment, and influencing mitochondrial function. These insights provide a foundation for novel therapeutic strategies targeting H₂S metabolism in NPC.
Research Article
Open Access