The metabolic syndrome is a trait of metabolic disorders that results from the increasing prevalence of obesity. Clinical manifestations include insulin resistance, hyperlipidemia, hyperuricemia, etc. Populations with high morbidity tend to be middle-aged and elder adults. With the advent of an ageing society, the incidence of metabolic syndrome will be higher. Since diacylglycerol (DAG) oil was first introduced in 1999, it has received extensive attention. DAG oils and related products have been distributed in markets in Japan, Europe, and the United States since 2001. This paper will review the effects of the new dietary oil, DAG, on the metabolic syndrome. It is hoped that DAG oil has the ability to replace traditional triacylglycerol (TAG) oil and control the morbidity of metabolic syndrome. This review article collected recent studies, and the results proved that dietary DAG is effective for reducing postprandial blood lipids and blood glucose, managing weight, and ameliorating insulin sensitivity.

Myopia is a relatively common disease at present, especially in the adolescent population is very high, and its prevalence increases with the passage of time, usually myopia will cause retinal detachment, glaucoma, etc., which may seriously lead to vision loss and blindness. Existing treatments include monocular lenses, contact lenses and refractive surgery, as well as the drugs atropine and pirrenzil. Studies have shown that most myopia treatments have little effect, are relatively short term, and have significant side effects. This article mainly summarizes the treatment methods of myopia, combined with the latest findings of clinical research, and put forward the possible future treatment methods.

Omega-3 polyunsaturated fatty acids (n-3 PUFA) are known to reduce cognitive degeneration and potentially prevent Alzheimer’s disease (AD). Unfortunately, while preventive measures like dietary therapy exist, there are few approved clinical healing therapies for AD. This study aims to investigate the effects of seed oil and fish oil separately in preventing Alzheimer’s disease. We conducted a systematic literature search to find experimental trials based on animal models and human observational studies examining the relationship between Alzheimer’s disease and oil supplements rich in n-3 PUFA. The study uses meta-analysis, t-tests, and regression analysis to determine the significance of each type of oil in regulating Alzheimer’s disease’s development. The results suggest that seed oil may help prevent AD by slowing cognitive deterioration, whereas fish oil may not. Overall, omega-3 fatty acids may serve as potential dietary supplements for improving memory and preventing Alzheimer’s disease.

In the recent years, the mentions of immunotherapy has become more and more frequent. What emerged along with it are the various types of immunotherapies. This essay includes an introduction to cancer and tumor with the definition, epidemiology, etiology, statistics such as curability regarding types, gender, and race and typical treatments of cancer along with how the immune system functions when targeting tumor cells and how they could potentially disfunction when deceived by tumor cells for example through immune editing. Then, leading on to the main topic to this recent and innovative treatment— immunotherapy. This essay emphasizes on two different types of immunotherapy which are dendritic cell therapy, and messenger RNA vaccine discussing their mechanism as separate treatments. Afterwards, I’ll proceed to discuss the combination of the two which is known as dendritic cell based mRNA vaccine which is a form of mRNA vaccine and it’s own mechanism, advantages, efficiency and current limitations in the conclusion.

Insulin analogs are currently the most often prescribed medications for treating type 2 diabetes mellitus (T2DM). However, because of the inherent flaws of the medications and the restrictions of the administration methods, there is no comprehensive plan for managing diabetes. As a result, it’s crucial to research comprehensive treatment plans based on the available medications and the traits of T2DM. Natural products play as key role in drug discovery. Although many articles have been published on the antidiabetic potential of natural products, few natural product-based molecules have been approved for the treatment of T2DM. It has been established that the compound 5,7-dihydroxy-6-(3-methybut-2-enyl)-isobenzofuran-(13H)-one from Nigella glandulifera Freyn et Sint (N. glandulifera) possesses antidiabetic activity, but little attention has been dedicated to its total synthesis. Herein, we attempt to reveal a new total synthesis of 5,7-dihydroxy-6-(3-methybut-2-enyl)-isobenzofuran-(13H)-one. The synthesis is simple, with few steps, and has potential for industrialization.

Carbohydrates are essential nutrients within the context of our daily dietary intake, serving a crucial function in the provision of energy for human metabolism, as well as exerting a significant influence on athletic performance and the subsequent process of recuperation. Carbohydrates, being a primary source of energy for the human body, hold significant significance in our daily existence. Carbohydrates serve multiple functions, including the reduction of body protein consumption, possession of detoxifying qualities, and potential contribution to an extended lifespan through acceptable ingestion. The appropriate consumption of carbohydrates significantly influences the overall health and quality of life of those without any specific health conditions. The dietary intake of an athlete plays a pivotal role in determining their performance on the field. Carbohydrates provide a primary energy source within the dietary regimen of athletes, playing a pivotal role in fueling explosive power, endurance, and other critical determinants of athletic success. The significance of carbs in relation to sleep should not be overlooked. The objective of this paper is to investigate the influence of carbohydrate consumption on both exercise performance and sleep quality. Additionally, this study will undertake a more extensive examination and analysis by include both athletes and individuals from the general population.

Multi-omics analysis is a relatively new approach which sets of data are combined for analysis. It integrates the genomic, epigenomic, transcriptomic, proteomic, and metabolomic data from diseased individuals and is capable of comparing the different changes in levels of each identified molecules with the assist of charts and graphs by information technologies, ultimately proposing potential biomarkers and correlations that are possible targets for cancer drugs. Lung cancer, nowadays is the most common cancer being diagnosed worldwide. Thus, lung cancer, amongst the remaining cancer, should not be overlooked. The pathogenesis and treatment of lung cancer is an urgent problem in the medical field that needs to be researched thoroughly. By integrating this new approach to the most common cancer, we try to find more possibilities for targeted drug development. We analyzed the data from the existing database to find out whether the control group and the disease group were up-regulated or down-regulated to analyze some targets, contributing to the development of targeted drugs.

Healthcare, as a fundamental component of human well-being, plays a pivotal role in shaping overall quality of life. This research investigates the extensive ramifications of the COVID-19 epidemic on the healthcare sector, encompassing the challenges and opportunities that have emerged in its wake. This study investigates the implications for hospital infrastructure through a comprehensive analysis of pertinent literature. The findings reveal significant deficiencies in essential resources such as ventilators and personal protective equipment (PPE). The evident manifestation of the psychological burden experienced by healthcare personnel highlights the imperative of allocating additional resources to support them. The advent of the pandemic has given rise to telemedicine and other digital alternatives, leading to a significant transformation in the field of healthcare delivery. Lockdowns, mask mandates, and other public health interventions are crucial in mitigating the transmission of the pathogen. Despite facing significant challenges, the ongoing pandemic has accelerated advancements in the field of medicine. This study contributes to the existing body of knowledge regarding effective strategies for addressing future pandemics and underscores the imperative of establishing a healthcare system that is adaptable and responsive. In the era following the COVID-19 pandemic, it is imperative to proactively tackle challenges and explore untapped opportunities in the healthcare sector by continuous research and assertive endeavors.

The secondary dysfunction of hepatitis B is usually gastrointestinal dysfunction, motor dysfunction, sensory disorders, sleep disorders, and further aggravation may even lead to liver failure. Among them, gastrointestinal dysfunction is the main symptom that troubles patients and is not conducive to prognosis. In this paper, the application of traditional Chinese and Western medicine rehabilitation in hepatitis B gastrointestinal dysfunction and related treatment mechanisms were reviewed. After studying related articles, it was found that: Traditional Chinese medicine rehabilitation pays attention to the overall function of patients, emphasizes the coordination of heart and rest, and focuses on traditional Chinese medicine regulation, body exercises, massage techniques, acupuncture, acupoint application and other methods; Modern medical rehabilitation attaches importance to the ability of patients to return to society, and mainly adopts physical therapy, occupational therapy, speech therapy and other methods. Among them, traditional Chinese medicine has various rehabilitation methods for gastrointestinal dysfunction of hepatitis B, and most of the current research focuses on traditional Chinese medicine and acupuncture. Modern medicine for rehabilitating this dysfunction, clinical research, and basic research are temporarily lacking. The rehabilitation method of integrated Chinese and Western medicine is more advantageous for the treatment of gastrointestinal dysfunction of hepatitis B. This article will provide new ideas for the rehabilitation of patients with gastrointestinal dysfunction of hepatitis B.

Alzheimer’s disease (AD) is a neurodegenerative disease with a worldwide prevalence of 760.5 per 100,000 inhabitants. Environment factors and genetic predispositions can influence an individual’s risk of developing AD. Recent research provided insights into the genetic mechanisms of AD, but a comprehensive database of drug-like molecules that can exacerbate or reduce AD risk remains unavailable. Here, we use machine learning to create a similarity map that reveals new putative drugs structurally similar to existing compounds known to be targeting pathways relevant in AD. We trained an autoencoder on a large drug database of over 14,000 drugs, with features derived from several modalities including molecular fingerprints. We then computed similarity scores based on these reduced dimensions. We show that our model is able to identify new compounds structurally similar to existing drugs linked to AD. We conclude that our model holds the potential to elucidate new compounds based on structural similarity and can be used to identify new drugs that affect critical pathways in AD.