Globally, breast cancer is the second-most common cause of cancer-related deaths among women. Recent research suggests that the gut microbiome may influence the development of breast cancer via hormonal, immunological, and metabolically mediated pathways. This review systematically summarizes the literature on the differences in gut microbiome diversity between women with breast cancer and without breast cancer. Women with breast cancer show consistently lower alpha diversity than women without breast cancer, particularly in postmenopausal women and those with metabolic dysfunction. These patterns suggest that gut microbiome diversity serves as an ecosystem-level indicator that interacts with the host context rather than acting as a standalone biomarker risk. This review also identifies the limitations in the current literature and the limitations of this review. For example, the evidence presented here is based on cross-sectional observational studies, and the methods for analyzing gut microbiota are highly heterogeneous. This review is non-systematic, focusing solely on gut microbiota diversity rather than functional/multi-site datasets. The insights presented in this review underscore the need for large, longitudinal studies of ethnically diverse cohorts and standardized methods to assess gut microbiota diversity, with the goal of determining how modifying gut microbiota diversity could provide a basis for developing personalized prevention/management strategies for breast cancer.

Due to observational studies on the role of type of food in have been inconsistent, the objective of this study was to apply the MR framework to evaluate the causal link between dietary intake and gastric ulcer to provide suggestions for preventive intervention strategies. Mendelian randomization test was conducted to assess the impact of 26 types of dietary habits and macronutrient intake on of GC and precancerous lesions. Genetically predicted alcoholic drinks per week were strongly connected with. Potential evidence , fat, and cooked vegetable intake might increase tumors. Salad/raw vegetable intake may decrease . Dietary composition and habits are causally related to GC and precancerous lesions. The biological heterogeneity of food processed in different ways and type of food may be a risk factor for GC. Intensive attention should be paid to lifestyle and diet management.

Ischemic stroke can be treated through anti-inflammation pathway.Coicis Semen is a kind of common traditional herbal medicine with long history. It is a Chinese medicine for both treatment and food. It contains fatty acids and esters, polysaccharides, flavonoids, triterpenes, alkaloids, sterols, lactam, starch, and other compounds, which play different effects and achieve the purpose of treatment. It has been proven to protect against ischemic stroke in TGFβ/ALK1 signaling pathway, which stimulates angiogenesis. This project aims to verify if Coicis Semen can treat ischemic stroke in anti-inflammation pathway. Both inflammatory factors and neutrophils were tested. Inflammatory factors were collected from bEnd.3 cells. The expression level of P-NF-kB, P-IkB and HIF-1α was evaluated by Western Blot. The production of NO was analyzed through Griess reaction. Zebrafish was applied to mimic the neutrophil production in ischemic stroke. The neutrophils in zebrafish embryos were stained by Sudan black and could be observed under optical microscope. Coicis Semen had positive effect on inhibiting expression of inflammatory factors and production of neutrophils. It can be proven that Coicis Semen treating ischemic stroke in anti-inflammation pathway is feasible.

Increasing evidence indicates that the vaginal microbiota (VMB) is closely associated with the development and progression of cervical diseases. Alterations in microbial composition have been observed across different stages of human papillomavirus (HPV) infection, cervical intraepithelial neoplasia (CIN), and cervical cancer. In healthy individuals, the VMB is typically dominated by Lactobacillus species, which contribute to the maintenance of an acidic environment and local immune balance. In contrast, vaginal dysbiosis is characterized by a reduction in Lactobacillus and an increased abundance of anaerobic bacteria, accompanied by elevated pH, disruption of epithelial barriers, and persistent inflammatory responses. Clinical and sequencing studies have reported that enrichment of specific bacterial genera, including Sneathia and Fusobacterium, is more frequently detected in high-grade cervical lesions, suggesting a potential association with disease severity. These microbial shifts may facilitate persistent HPV infection and promote lesion progression through multiple biological pathways. In addition, emerging evidence suggests that modulation of the VMB, particularly through probiotic supplementation with Lactobacillus crispatus, may support HPV clearance and improve microbial stability in early disease stages. By integrating findings from recent studies, this review outlines the dynamic changes of key microbial taxa during cervical disease progression and discusses their potential clinical relevance. These observations provide a quantitative reference for future investigations and highlight the possible value of microbiome-based strategies in cervical disease risk assessment and management.

The study aimed to develop and evaluate a novel denture adhesive patch based on catechol-functionalized polyvinyl alcohol (Cat-PVA), inspired by mussel adhesion mechanisms, to overcome the limitations of conventional denture adhesives and improve denture retention under moist and dynamic oral conditions. An edentulous jaw model with complete dentures was employed to compare Cat-PVA adhesives with a commercial product (Polident®). Biocompatibility was investigated using human gingival epithelial cells (HGECs) with CCK-8 assays. Spectroscopic analysis confirmed successful catechol incorporation, with a dose-dependent increase in catechol content. Cat-PVA adhesives exhibited significantly higher tensile and shear adhesion compared with unmodified PVA (P < 0.05). Cat-PVA3 denture adhesive demonstrated the strongest adhesion, maintaining nearly complete retention for 8 h under simulated saliva flow, while showing controlled degradation (~80% at 8 h). In the complete denture model, Cat-PVA3 achieved significantly greater tensile and shear bond strengths than Polident®(P < 0.05). Cat-PVA3 exhibited optimal performance, combining robust adhesion, prolonged retention, controlled disintegration, and excellent biocompatibility.  Cat-PVA patches represent a promising, clinically translatable bioinspired strategy for denture fixation.

As times now go on, health awareness has raised, however mental health problems in crowded city environments have grown more. Depression is a severe disorder and important indicator of mental health, now it’s a public health concern related to urbanization. This paper looks at how various kinds of residential built environment factors affect people’s health awareness and depression lev-els and also looks at how health awareness can be a reason for something. According to 775 ques-tionnaires collected in the main urban area of Zhengzhou, multiple linear regression and mediation effect analysis were conducted. Depression was judged with the HADS questionnaire and health awareness through a survey questionnaire, Results show that: (1) Green view ratio raises depres-sion but NDVI and average building height lessen it. (2) Green view ratio, green space quantity, and road network density bring about higher health awareness, concurrently fewer people, sky openness, transit stations, and walkability also improve health awareness. (3) Health awareness acts as a mediator linking improved environmental elements like greenness, streets, and vegetation, to lower depressive illnesses. On contrast, it also explained how certain specific urban arrangement like abundant foliage, a lot of open sky, concentrated residential pattern, pedestrian-friendly infra-structure, a lot of public transport hubs etc. associated itself with higher level of depressive symp-toms This study proves that improving the residential built environment can lead to better mental health both directly and indirectly as a result of health awareness.