Obesity has become an increasingly serious global issue in recent years, leading to a myriad of health concerns for a growing population. Consequently, the quest for rational and safe methods to combat excess body fat has emerged as a mainstream demand among consumers. This paper focuses on tea polyphenols as the primary subject of investigation, employing gut microbiota as a mediator to explore and summarize existing research regarding the anti-obesity effects of tea polyphenols. Current reports suggest that the mechanisms by which tea polyphenols exhibit anti-obesity effects primarily encompass two aspects. Firstly, tea polyphenols can regulate the composition of the gut microbiota, primarily targeting the Firmicutes and Bacteroidetes phyla. This regulation occurs both in their digested state and undigested form, with a greater emphasis on their undigested state. Tea polyphenols primarily function by reducing the abundance of Firmicutes while increasing that of Bacteroidetes, thereby enhancing gut microbiota diversity to exert anti-obesity effects. Secondly, the metabolites of tea polyphenols also play a role in modulating gut microbiota, with phenolic acid compounds being the key metabolites responsible for anti-obesity effects. Compared to the parent tea polyphenols, phenolic acid compounds exhibit higher bioavailability and biological activity.

Thalidomide, a drug initially introduced in the late 1950s, stands as a poignant reminder of the complexities of drug discovery. Initially hailed for its sedative properties, its widespread use led to a tragic medical disaster, with thousands of infants born with severe congenital malformations. This catastrophe prompted global reforms in drug testing and approval processes. However, the story of thalidomide took a turn as subsequent research unveiled its potential therapeutic applications, particularly its anti-inflammatory and immunomodulatory properties. This article delves into thalidomide’s transformative journey, from its tragic beginnings to its cautious reintroduction in medical therapeutics. The narrative underscores the balance between innovation, risk, and ethical responsibility in medicine. Furthermore, the article explores five cutting-edge technologies reshaping thalidomide’s therapeutic potential: molecular modifications and analogues, nanoparticle-based delivery systems, prodrug strategies, gene therapy integration, and enhanced formulations. Each technology offers unique avenues to enhance thalidomide’s efficacy, safety, and applicability. The advancements collectively signify the evolving landscape of pharmaceutical design, emphasizing the potential of tailored treatments that prioritize patient well-being. In conclusion, thalidomide’s journey from tragedy to therapeutic innovation serves as a testament to the resilience of medical science, highlighting the importance of continuous learning, adaptation, and responsible innovation in the realm of drug discovery.

This paper mainly uses the method of literature review to sort out and analyze the research and application fields of minimally invasive robot technology,combined with experimental research and case analysis,to explore the development trend and future development direction of minimally invasive robot technology. The research of minimally invasive robot technology has been relatively mature,but its limitations still exist,such as the accuracy of surgical instruments,the control mode of robots,and the safety in surgery.The development of minimally invasive robot technology in the future needs to consider the factors of technology, law and ethics. At the same time, it is also necessary to continuously promote the development of minimally invasive robot technology in the laboratory and practice, so as to achieve better surgical results and serve more patients. In the future development, minimally invasive robot technology will become more and more mature and new application fields will emerge, but it is still necessary to actively explore unknown areas and continuously promote the development, optimization and application of minimally invasive robot technology. This study discusses and analyzes the development trend and future development direction of minimally invasive robot technology, and puts forward suggestions and prospects for the optimization and development of minimally invasive robot technology.

The development of high-throughput screening technologies has revolutionized the field of drug discovery by significantly improving the efficiency of compound library screening. Traditional screening methods, such as manual screening and biochemical assays, were time-consuming and limited in their ability to identify lead compounds. However, the advent of high-throughput screening technologies has overcome these limitations and provided researchers with a more efficient and effective approach. This review begins by examining the background, characteristics, and limitations of conventional screening methods. These methods often required large amounts of time, resources, and labor, making them impractical for large-scale compound screening. In recent years, some new technologies have emerged, including virtual screening, image analysis, prediction methods, and microarray-based screening. Each of these approaches has its own strengths and limitations, but collectively they have greatly enhanced the efficiency and accuracy of compound identification. These viewpoints highlight the successful application of these technologies in identifying lead compounds for various therapeutic targets. Finally, the review envisions the future development of high-throughput screening technologies. It emphasizes the need for continuous optimization and innovation to further improve the efficiency and effectiveness of compound identification. The ultimate goal is to shorten drug development timelines and provide high-quality lead compounds for the benefit of patients. In conclusion, the emergence of high-throughput screening technologies has significantly improved the efficiency of compound library screening and provided better lead compounds for drug discovery. Ongoing advancements in these technologies hold great promise for the future of pharmaceutical research and development.

The reasons for the significant decrease in cancer incidence in the past decade among residents of Wuyingshan Community, Tianqiao District, Jinan City, Shandong Province, where the author lives, are certainly comprehensive and multifaceted. Due to time and energy constraints, this paper takes the perspective of the creation of a National Sanitary City in Jinan and the widespread use of tap water purification equipment by residents in the Wuyingshan Community, and uses the sample sampling method and comparative research method to indirectly prove the relationship between water pollution and the incidence of common cancers among residents in the Wuyingshan Community by investigating the effects of the quality of residents’ drinking water on residents’ tumors. The results of the study show that there is a positive correlation between water pollution and the incidence of common cancers, and that the creation of the National Sanitary City and its continuous management of water pollution effectively reduce the incidence of common cancers in the community, and that the residents contribute to the further purification of tap water; on the other hand, residents who do not pay attention to the quality of drinking water are prone to the occurrence of common cancers. In order to sustainably reduce the level of urban water pollution and maintain drinking water quality that meets internationally accepted health standards, this paper makes several recommendations from the dimensions of water quality legislation, production and living needs, water quality monitoring, and sewage treatment.

The prevalence of obesity and overweight has emerged as a significant public health concern on a global scale, as societies continue to progress. Consequently, the use of scientific methods for reducing body fat has become a crucial approach in mitigating associated health concerns. The dietary habits of individuals play a crucial role in weight control and have a substantial influence on the efficacy of scientific approaches to fat reduction. This study endeavors to examine the correlation between eating habits and scientific fat loss by conducting a comprehensive literature review and data analysis. Specifically, it desires to explore the interplay between food frequency, dietary surroundings, and dietary psychology, and their impact on the efficacy of scientific fat loss methods. The primary objective of this study is to investigate the correlation between dietary environment and scientific fat loss. The objective is to establish a scientific foundation and offer direction for the creation of effective and evidence-based strategies for fat reduction. By implementing more robust interventions and educational programs focused on dietary habits, it is possible to foster the cultivation of wholesome eating practices, diminish the prevalence of obesity, and enhance the general well-being of the populace.

Photocured hydrogels are materials with great potential, offering a novel approach in the treatment of bone defects. They exhibit excellent biocompatibility, tunable degradation characteristics, and the ability to incorporate cells and growth factors. This paper explores the mechanisms and advantages of photocured hydrogel applications in the treatment of bone defects, focusing on bone formation promotion, drug-loading and antimicrobial properties, and enhancement of vascularization in the surrounding tissues. Research indicates that photocured hydrogels can serve as scaffolds, drug delivery systems, and tissue engineering materials, promoting bone cell proliferation, osteogenic differentiation, inhibiting bone resorption and osteolysis, fostering vascularization, and providing drug-loading antimicrobial effects. Nevertheless, the application of photocured hydrogels in the treatment of bone defect diseases faces challenges, such as long-term stability and interface adaptability. Further research and development are required to overcome these challenges, facilitating the widespread clinical use of photocured hydrogels and improving the treatment outcomes and quality of life for patients with bone defects.

Statistics show that among malignant tumors, pancreatic cancer has the poorest prognosis. Cancer has a low likelihood of survival, and early cancer diagnosis is challenging. The major therapies currently used include surgery, chemotherapy, and radiation, although the outcomes are not optimal. Treatments for pancreatic cancer using immunotherapy now appear more promising because to developments in molecular biology. The primary pancreatic cancer treatments will be analyzed and evaluated in this study, and it will be concluded that immunotherapy is the most promising course of action. The usage of patient range, toxicity, and other side effects are some of the difficulties, although it is still in the research and development stage.

Antibiotics, as a typical new pollutant in environmental media, have important implications for the treatment of water sources, soil, livestock, and humans. This article summarizes the effects of antibiotics on sewage, water sources, soil, water circulation, and plankton in the water, as well as the underlying reasons, by analyzing and summarizing other papers. It also provides analysis and solutions for antibiotics. Not only that, this article also reviews the reasons for the excessive use of antibiotics in clinical treatment and the impact of antibiotic resistance on clinical treatment. It also reviews the emergence and treatment of antibiotic resistance in the human body. Through the above plan, this article summarizes the impact of antibiotics on the environment and the human body.

Insomnia is a common sleep disorder that affects the typical quality of life of people. Different treatment strategies are required for insomnia caused by specific factors, such as environment and genetics. Currently, the two main categories of insomnia treatments are cognitive behavioral therapy for insomnia (CBT-I) and pharmacotherapy. However, each treatment has distinctive limitations. CBT-I lacks accessibility and certified facilitators, while pharmacotherapy is more prone to result in negative side effects, addiction, and physiological tolerance. To get over these limitations, it is necessary to come up with new alternative therapies to deal with insomnia effectively. This review is intended to summarize the different causes of insomnia and the latest existing treatments for insomnia. Based on previous studies, this study provides new ideas for future insomnia treatments.